
Victory
for Mrs Clinton was widely expected but it gives her momentum ahead of
the "Super Tuesday" primaries in 11 states next week.
"Tomorrow this campaign goes national," she told cheering supporters.
Mr Sanders has congratulated her but said the campaign was just beginning.
With almost all the votes counted Mrs Clinton leads Mr Sanders by an almost 50-point margin.
Eight out of 10 black voters backed Mrs Clinton, exit polls suggested, a key section of the Democratic electorate.
It is Mrs Clinton's third victory in four contests, after wins in Iowa and Nevada. She lost to Mr Sanders in New Hampshire.
Eight years ago, she lost the South Carolina primary overwhelmingly to then Senator Barack Obama.
It
was a different story this time. Soon after polls closed she told
supporters: "You sent a message - in America when we stand together,
there is no barrier too big to break."
On the Republican side, billionaire Donald Trump leads a field that has dwindled to five from 12 a month ago.
He won the Nevada caucus on Wednesday by a wide margin - correspondents say he is beginning to look unstoppable.
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